Compare Cymbalta vs. Wellbutrin Side Effects, Uses and Dosage

Cymbalt vs. Wellbutrin quick comparison of differences

What is Cymbalta? What is Wellbutrin? How do they work?

Cymbalta

Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant used for treating depression, anxiety disorders, and pain. Other SNRIs include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq).

Cymbalta prevents the reuptake of the neurotransmitters serotonin and epinephrine by nerves after they have been released, thereby increasing the effect of serotonin and norepinephrine in the brain.

Wellbutrin

Wellbutrin (bupropion) is an antidepressant used for treatingmajor depression and SAD (seasonal affective disorder). Off-label uses for Wellbutrin include post-traumatic stress syndrome (PTSD), attention deficit hyperactivity disorder (ADHD), anxiety, social phobia, and neuropathic pain.

Wellbutrin works by inhibiting the reuptake of the neurotransmitters dopamine, serotonin, and norepinephrine. This results in more of these chemicals available to transmit messages to other nerves. Wellbutrin is unlike other antidepressants in that its major effect is on dopamine, an effect not shared by the selective serotonin reuptake inhibitors (SSRIs) or the tricyclic antidepressants (TCAs).




Physical Symptoms of Depression in Pictures


What are the uses for Cymbalta vs. Wellbutrin?

Cymbalta uses

Wellbutrin uses

What are the side effects of Cymbalta vs. Wellbutrin?

Cymbalta side effects

The most common side effects of duloxetine are

Increased blood pressure can occur and should be monitored. Seizures have been reported. Sexual dysfunction (decreased sex drive and delayed orgasm and ejaculation) has been associated with duloxetine.

Some patients may experience withdrawal reactions upon stopping duloxetine. Symptoms of withdrawal include:

  • dizziness,
  • anxiety,
  • nausea,
  • vomiting,
  • nervousness,
  • diarrhea,
  • irritability, and
  • insomnia.

The dose of duloxetine should be gradually reduced when therapy is discontinued to prevent symptoms of withdrawal.

Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of duloxetine or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.

Wellbutrin side effects

Warning: Four of every 1000 persons who receive bupropion in doses less than 450 mg/day experience seizures. When doses exceed 450 mg/day, the risk increases ten-fold. Other risk factors for seizures include past injury to the head and medications that can lower the threshold for seizures. (See drug interactions.)

Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of bupropion or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidality, or unusual changes in behavior.

The most common side effects associated with bupropion include:

In some people, the agitation or insomnia is most marked shortly after starting therapy.

Less common side effects include:

What drugs interact with Cymbalta vs. Wellbutrin?

Cymbalta drug interactions

  • Duloxetine should not be used in combination with a monoamine oxidase inhibitor (MAOI) such as phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within 14 days of discontinuing the MAOI. At least 5 days should be allowed after stopping duloxetine before starting an MAOI. Combinations of SNRIs and MAOIs may lead to serious, sometimes fatal, reactions including very high body temperature, muscle rigidity, rapid fluctuations of heart rate and blood pressure, extreme agitation progressing to delirium, and coma. Similar reactions may occur if duloxetine is combined with antipsychotics, tricyclic antidepressants or other drugs that affect serotonin in the brain. Examples include tryptophan, sumatriptan (Imitrex), lithium, linezolid (Zyvox), tramadol (Ultram), and St. John’s Wort.
  • Fluoxetine (Prozac, Serafem), paroxetine (Paxil, Paxil CR, Pexeva), fluvoxamine (Luvox), and quinidine increase blood levels of duloxetine by reducing its metabolism in the liver. Such combinations may increase adverse effects of duloxetine.
  • Combining duloxetine with aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), warfarin (Coumadin) or other drugs that are associated with bleeding may increase the risk of bleeding, because duloxetine itself is associated with bleeding.
  • Duloxetine has an enteric coating that prevents dissolution until it reaches a segment of the gastrointestinal that has a pH higher than 5.5. In theory, drugs that raise the pH in the gastrointestinal system (for example, Prilosec) may cause duloxetine to be released early while conditions that slow gastric empyting (for example, diabetes) may cause premature breakdown of duloxetine. Nevertheless, administration of duloxetine with an antacid or famotidine (Axid) did not significantly affect the absorption of duloxetine.
  • Duloxetine may reduce the breakdown of desipramine (Norpramine), leading to increased blood concentrations of desipramine and potential side effects.

Wellbutrin drug interactions

  • Bupropion should be used cautiously in patients receiving drugs that reduce the threshold for seizures. Such drugs include prochlorperazine (Compazine), chlorpromazine (Thorazine), and other antipsychotic medications of the phenothiazine class. Additionally, persons who are withdrawing from benzodiazepines [for example, diazepam (Valium), alprazolam (Xanax)] are at increased risk for seizures.
  • Carbamazepine (Tegretol) may reduce the effect of bupropion by reducing the blood concentration of bupropion. Monamine oxidase inhibitors should not be combined with bupropion because of the risk of severe reactions. At least 14 days should elapse between discontinuation of an MAOI and initiation of bupropion. Bupropion may affect the action of warfarin (Coumadin).
  • Ritonavir (Norvir) may increase the breakdown and elimination of bupropion. In some studies ritonavir reduced the concentration of bupropion in the body by 22% to 66%.

Are Cymbalta and Wellbutrin safe to take if I am pregnant or breastfeeding?

Cymbalta safety

  • Duloxetine is excreted into the milk of lactating women. Because the safety of duloxetine in infants is not known, breastfeeding while on duloxetine is not recommended.

Wellbutrin safety

  • There are no adequate studies of bupropion in pregnant women. In one study, there was no difference between bupropion and other antidepressants in the occurrence of birth defects. Bupropion should only be used in pregnancy if the benefit outweighs the potential risk.
  • Bupropion is secreted in breast milk.

REFERENCE: FDA Prescribing Information


Reviewed on 12/12/2017

References


REFERENCE: FDA Prescribing Information

    The Best Prices on Ethicon Products!
    Source link

    Medical News Headlines

    Primary Amenorrhea: Causes & Menstrual Cycles – Gynecology | Lecturio

    The Best Prices on Ethicon Products!
    The Best Prices on Ethicon Products!
    This video “Primary Amenorrhea: Causes & Menstrual Cycles” is part of the Lecturio course “Gynecology” ► WATCH the complete course on http://lectur.io/primaryamenorrhea

    ► LEARN ABOUT:
    – Primary Amenorrhea
    – Normal menstrual cycles
    – Menstrual cycle terminology
    – Common causes of primary amenorrhea
    – Top causes of primary amenorrhea

    ► THE PROF:
    Lynae Brayboy from Brown University has been teaching OB/GYN for a decade. She is double-board certified in OB/GYN as well as Reproductive Endocrinology and Infertility. She teaches undergraduates, medical students, residents and fellows and has also won multiple teaching awards.

    ► LECTURIO is your single-point resource for medical school:
    Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/primaryamenorrhea

    ► INSTALL our free Lecturio app
    iTunes Store: https://app.adjust.com/z21zrf
    Play Store: https://app.adjust.com/b01fak

    ► READ TEXTBOOK ARTICLES related to this video:
    Amenorrhea in Adults — Causes and Management
    http://lectur.io/primaryamenorrheaarticle

    ► SUBSCRIBE to our YouTube channel: http://lectur.io/subscribe

    ► WATCH MORE ON YOUTUBE: http://lectur.io/playlists

    ► LET’S CONNECT:
    • Facebook: https://www.facebook.com/lecturio.medical.education.videos
    • Instagram: https://www.instagram.com/lecturio_medical_videos
    • Twitter: https://twitter.com/LecturioMed

    source
    [

    Medical Videos – Primary Amenorrhea: Causes & Menstrual Cycles – Gynecology | Lecturio #Medical #Videos

    Web MD App Review

    The Best Prices on Ethicon Products!
    The Best Prices on Ethicon Products!
    As featured on WDAM’s News 7 Sunrise, Kenneth McLaurin presents the WebMD App Review.

    source
    [

    Medical Videos – Web MD App Review #Medical #Videos

    Slow Cooker Lemon Garlic Chicken Recipe | WebMD

    The Best Prices on Ethicon Products!
    The Best Prices on Ethicon Products!
    Pair this delicious slow-cooker lemon garlic chicken with pasta or brown rice for a healthy, tasty meal.

    Subscribe to WebMD here: https://www.youtube.com/user/WebMD

    Follow WebMD here:
    Website: http://webmd.com
    Facebook: https://www.facebook.com/WebMD/
    Pinterest: https://www.pinterest.com/webmd/
    Twitter: https://twitter.com/WebMD
    Instagram: https://www.instagram.com/webmd/

    source
    [

    Medical Videos – Slow Cooker Lemon Garlic Chicken Recipe | WebMD #Medical #Videos

    Could multivitamin use in pregnancy protect children from autism?

    The Best Prices on Ethicon Products!

    The Best Prices on Ethicon Products!
    Source link

    Five vascular diseases linked to one common genetic variant

    The Best Prices on Ethicon Products!
    Genome-wide association studies have implicated a common genetic variant in chromosome 6p24 in coronary artery disease, as well as four other vascular diseases: migraine headache, cervical artery…

    The Best Prices on Ethicon Products!
    Source link

    Colorblindness | WebMD

    The Best Prices on Ethicon Products!
    The Best Prices on Ethicon Products!
    The term color blindness is a bit misleading. Only the rarest, most severe type makes everything looks white, black and gray. Learn more about the condition.

    Subscribe to WebMD here: https://www.youtube.com/user/WebMD

    Follow WebMD here:
    Website: http://webmd.com
    Facebook: https://www.facebook.com/WebMD/
    Pinterest: https://www.pinterest.com/webmd/
    Twitter: https://twitter.com/WebMD
    Instagram: https://www.instagram.com/webmd/

    source
    [

    Medical Videos – Colorblindness | WebMD #Medical #Videos

    Hyperemia: Causes, symptoms, and treatment

    The Best Prices on Ethicon Products!
    What is hyperemia? In this article, learn about the different types of hyperemia, including passive and active hyperemia. How can it be prevented?

    The Best Prices on Ethicon Products!
    Source link

    Raw milk may prevent allergy and asthma, but is it safe?

    The Best Prices on Ethicon Products!
    More people are choosing to drink unpasteurized milk. Research shows that it can reduce allergy and asthma, but raw milk can also contain deadly bacteria.

    The Best Prices on Ethicon Products!
    Source link

    These neurons may 'tell us' to keep eating, even when we are full

    The Best Prices on Ethicon Products!
    New research in mice identifies a class of neurons in the brain’s ’emotional hub’ that encourages the mice to keep eating even when they are full.

    The Best Prices on Ethicon Products!
    Source link